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Here's the skinny on the 2 Day a Week Diet, which is sometimes referred to as the 5-2 or Fast Diet.  Simply eat normal meals five days a week, and cut back to only 500 calories (guys can eat 600 calories) on two nonconsecutive days.

It's worked wonders for us.  Ruth has lost 16 pounds in four months after going on the diet.  And Nancy, who never loses on any diet, has lost 6.  But we're not the only happy losers. Scientific studies have proven the effectiveness of the method. For example, one study at the University Hospital, South Manchester, England, found that 65 percent of 2-day-diet participants lost weight compared to only 40 percent of those on more typical, every-day diet plans. Of course, you should check with your doctor before starting this or any other diet to make sure it’s suitable for you.

For background and more information about the diet, here are some links:
  Short Fasts for Weight Loss vs. Traditional Diets, Wall Street Journal
  The UK's Hot New 5:2 Diet Craze Hits The U.S., Forbes Magazine
  The Latest Research on Intermittent Fasting, Diane Rehm Show